To add to these anecdotes, Ron Konopka (notably discovered the Period gene, which controls the period of circadian rhythms in Drosophila) was denied tenure and subsequently exited science.

Read more on his wiki:

https://en.wikipedia.org/wiki/Ron_Konopka

He died in 2015, about 2 years before Hall, Rosbash, Young won the nobel prize for cloning the Period gene.